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As Secretary of Health, Education, and Welfare Joseph Califano, Jr., ruefully noted in the late-1970s when he stepped up the federal governments campaign against smoking, Women who smoke like men, die like men. By 1985, lung cancer had surpassed breast cancer as the leading cause of cancer deaths among women

Safer Chemical Profile Cigarettes produce nearly 600 chemical compounds through burning tobacco, including tar and carbon monoxide

Reynolds has framed the deal as a way to cope with a long-running slide in cigarette sales as smoking is banned in more public places and more consumers eschew a habit that is known to cause cancer and other serious health problems

[9] Bartolom de las Casas described how the first scouts sent by Christopher Columbus into the interior of Cuba found: men with half-burned wood in their hands and certain herbs to take their smokes, which are some dry herbs put in a certain leaf, also dry, like those the boys make on the day of the Passover of the Holy Ghost