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ROS cause oxidative stress, which damages cellular proliferation, metabolism, and health, and can be involved in the development of several cardiovascular (e.g., atherosclerosis), respiratory (e.g., chronic obstructive pulmonary disease, asthma), and neurodegenerative disorders (e.g., Parkinsons disease, multiple sclerosis) as well as diabetes, rheumatoid arthritis, and some types of cancers (e.g., lung, colorectal) (Domej et al., 2014

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Subsequent studies confirmed these results [103], but the mechanism still remained not fully understood