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These include: Obesity , particularly central (abdominal) obesity, with risk increasing substantially when BMI exceeds 30 kg/m Type 2 diabetes and insulin resistance, present in up to 70% of people with NAFLD Dyslipidaemia , characterised by high triglycerides and low HDL cholesterol Metabolic syndrome , a cluster of conditions including high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol levels Polycystic ovary syndrome (PCOS) , which involves insulin resistance Lifestyle factors also play a substantial role

For example, a patient who tests positive for street drugs while getting outpatient care would be discharged and told to go to residential rehab

Whether NNK mediates other pancreatitis responses through these receptors is undetermined