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Additionally, sulforaphane exhibits antioxidant effects by increasing superoxide dismutase (SOD), glutathione peroxidase (GPx) activity, reducing malondialdehyde (MDA) and nitric oxide (NO) levels in the injured brain ( Sulforaphane exerts anti-neuroinflammatory effects by suppressing microglial activation, reducing TNF-, IL-1, IL-6

GPx1 deficiency also enhanced angiotensin II-mediated cardiac hypertrophy, increasing total cardiac mass, left ventricular mass, and left ventricular cardiomyocyte cross-sectional area compared to the changes found in wild type mice

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Even with the recent improvements due to (adjuvant) immunotherapy treatment, collectively, more than 50% of patients with NSCLC still die of lung cancer within 5 years [1, 4]