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First, multiple imputation was performed for covariates with missing values, including PIR, BMI, maternal age at childbirth, birth weight, smoking during pregnancy, asthma, and health insurance status, with the mice package in R employed to reduce potential bias associated with missing data

Among the documented hazards associated with smoking, generation of reactive oxygen species (ROS) and alteration of gap junctional complexes are tightly associated with modulation of repair mechanisms

Though fainting is usually not a cause of concern, it is important to seek medical attention if it happens too often