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It is predominantly metabolised by CYP3A4 in the liver into the N-monodesmethyl (M2) metabolite, which exhibits anti-tubercular activity, albeit with approximately five times less potency than the parent drug

Based on 2013 statistics from the American Cancer Society and the World Lung Foundation, 15.6 per cent of male teenagers smoke tobacco daily in the UAE, as do 18.1 per cent of men

Despite this evidence, many American states tax non-combustible nicotine products at rates comparable to cigarettes