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5557 Hoffmann et al 16 suggested that cigarette smoke induced morphologic changes in the COPD epithelium by significantly increasing the expression of Mfn1/2 and Opa1, which were accompanied by increased levels of the proinflammatory mediators such as IL-8, IL-6 and IL-1

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The directive is meant to make it less attractive to use tobacco products , in particular among young people, by requiring health warnings on packs of cigarettes, banning misleading packaging, and limiting the advertising of, and sponsorship by, tobacco companies