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It suggests that each year of smoking adds approximately 23 years to the risk advancement period, meaning that former smokers need a longer duration of abstinence than their smoking history to fully mitigate their increased risk ( 42 )

It should be decreased if you experience signs of overdose: read the chapter on precautions for use and do not hesitate to ask your pharmacist for advice

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21 In general, a dose-response relationship exists between the amount and duration of smoking and the risk of adverse health outcomes