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23,25 Using cross-sectional data, Mitchell et al's 23 study with 12- to 17-year-old never smokers found that images of all four standardized cigarette packs with different pack structures (regular, beveled-edge, slim, shoulder box) were considered off-putting, with the vast majority (87%) indicating that they would select none of the packs if offered

After exposing mice both chronically and acutely to cigarette smoke, the researchers noticed a substantial disruption of their natural circadian clocks, which only worsened with increased tobacco exposure