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Methods Design The experiment design included 2 phases: Phase 1: initial casecontrol phase comparing the taste sensitivity level of various parts of the tongue between smokers and non-smokers, Phase 2: A follow-up study during 6 to 12 months, looking at the variation of taste sensitivity in smokers after smoking cessation

8 In contrast to CD, cigarette smoke does not negatively impact clinical outcomes in patients with established UC and may be protective against disease risk, progression, relapse, and adverse outcomes

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