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Key Takeaways Folks who smoke weed heavily may be more likely to develop bipolar disorder or depression Among the nearly 70,000 people studied who had cannabis use disorder, there was a two to three times greater risk for either bipolar disorder or depression But the researchers stressed the findings do not prove that heavy marijuana use causes either mental health disorder FRIDAY, May 26, 2023 (HealthDay News) -- Heavy users of marijuana might face an increased risk of bipolar disorder and depression, a new study suggests