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Cannabis Globally, cannabis is the most widely used illicit drug, and its usage has increased over the past two decades.[50] The UN Office on Drugs and Crimes (UNODC) World Drug Report estimates that in 2020, more than 4 percent of the global population aged 1564 (209 million people) had used cannabis in the past year.[51] Marijuana use, cultivation, and global traffic are all on upward trajectories