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[24] These genetic risk factors do not operate in isolation from environmental risk factors, rather they often function synergistically to influence smoking behavior

This is the only way to get into Nome other than the Iditarod Trail, as the rest of the roads in Nome do not connect to other parts of Alaska

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Bringing these aspects of their smoking experience to the forefront helps them develop a better grasp on the ways they normally respond to the urge to smoke, and the frustration that arises when they refrain from smoking