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The discovery of these genes could, therefore, help improve the nitrogen use efficiency of some types of tobacco, as well as other commercially important crops -- ultimately reducing the need for chemical fertilizers The impact of Burley's lower nitrogen use efficiency on its metabolism and growth means that some plant variants contain increased levels of nicotine, other alkaloids, and nitrites, resulting in higher levels of tobacco-specific nitrosamine (TSNA) compounds in their leaf

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However, if you stick to the recommended instructions you should not have any problems

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