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extracted DNA from induced sputum in asthma patients and profiled microbial communities using 16S rRNA pyrosequencing, the results showed ex-smokers have a higher prevalence of phylum Fusobacteria , the phyla Firmicutes and Bacteroidetes , and a lower abundance of bacteria from phylum Proteobacteria compared with never-smokers

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Regional manufacturing hubs show distinct patterns: Chinese manufacturers dominate volume production, while European and North American facilities focus on specialized high-compliance units