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3 Impact of tobacco smoke on enzymatic drug metabolism Tobacco smoke is a complex mixture of polycyclic aromatic hydrocarbons (PAHs), ammonia, aromatic amines, phenols, carbonyls, hydrocyanic acid, and N-nitrosamines (Hoffmann and Hoffmann, 1997)

Much of the central part of the range is within the Beaverhead-Deerlodge National Forest, although manymostly smallpatented mining claims exist within the forest boundary

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The SPME fiber was inserted manually into the vial containing the material and placed in an oven with shaking using magnetic stirrer and maintained at 50 C for 30 min