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Although the two stressors (task DEMAND and nicotine STATE) did not interact directly, the attentional demands of the PFT concurrent with the presence/absence of nicotine likely produced a dynamic break with homeostasis in response to allostatic load [16], revealing differential disease-relevant behavioral (attentional lapses) and neurobiological (network FC) SUBGROUP*STATE interactions, i.e., two distinct SUBGROUPs with variable cognitive capacity

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