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A central mechanistic finding is that NRF2 activity persisted under chronic exposure without an increase in transcript levels

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SIGNS OF DRUG USE Signs of drug use include: Spending less time with family and friends Spending more time away from the home Changing friend suddenly Suddenly losing interest in hobbies/sports Sudden and drastic changes in appearance Sudden and drastic change in weight Changes in behavior Increase in irritability Argumentative behavior Changes in grades Skipping class Staying out late/past curfew Running away Shoplifting or stealing including from friends and family Finding drugs or drug paraphernalia in their room including razors, mirrors, spoons, and lighters Of note, these symptoms are very similar to the teens with depression and other mental illness