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Nicotine can cause dopamine (a chemical that often causes pleasant feelings) to affect the brain, which may contribute to people becoming addicted to it

[102] Furthermore, in spring training, the Angels and Ohtani agreed to allow him to play without limitations or restrictions and drop the "Ohtani Rules", [104] a plan the Angels mirrored from Ohtani's schedule in Japan and had implemented since his 2018 rookie season that restricted his usage to a schedule of pitching once a week and hitting only three to four times between starts

And many vape shops in cities sell unapproved brands that arent as well-known

The nicotine comes from tobacco extraction or synthesis, but it's held in a plant fiber base rather than loose tobacco