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The market for raw tobacco remains small because manufacturers are more likely to process cured leaves into cigar filler and pipe and cigarette tobaccos than raw leaves.

The nose-only method of forced smoke inhalation is a contentious research method used by a research group at the Centenary Institute, Sydney, in which mice are constrained in a tube and attached to a smoking machine, where they are forced to smoke up to 12 cigarettes twice a day for up to 18 weeks before being killed to measure disease indicators

As a result, preventive measures are typically general ones

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