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[18] Regulation of tobacco products (part 3): Hearings before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce (Serial 103-171), 103 rd Cong

10 , 15 Human Cancer : The amount of aldehyde compounds, carbon monoxide, and tar found in one shisha smoking session is 430 times more than in a single session of cigarette smoking and are potentially known human carcinogens along with other toxic substances

A dose-dependent effect has also been observed, with a 7% increase in the overall risk of death for every five pack-years increase in smoking history [113]

Historically speaking, its main causes have been alcohol, tobacco and poor oral hygiene, but in recent decades HPV has become a significant risk factor, especially for younger people and relatively well-off patients