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For purposes of this paragraph (b)(2)(v)(B), significant changes or errors are changes or errors external to the care provided, and that CMS determines may lead to misleading or inaccurate results that negatively impact the measure's ability to reliably assess performance

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Immunologic effects Smoking profoundly impacts both innate and adaptive immunity, often aggravating pathological immune responses while suppressing defensive mechanisms [19]

These non-synthetic herbicides are contact herbicides, meaning they disrupt the cells in the plant tissue they come into contact with, therefore requiring precise and often more frequent application to kill the entire plant