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Campbell River, for instance, has a bylaw that defines a nuisance odour as: An odour in the air that is harmful, poisonous, disgusting, repulsive, very unpleasant, offensive, or interferes with the use or enjoyment of property, endangers personal health or safety, or is offensive to the senses and causes inconvenience or annoyance to a person with a normal sense of smell. In that community, if an odour rises to that level, a person affected by it can complain to the municipality

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Our observation that CSE-EVs failed to induce malignant urothelial cell transformation in long-term assays is surprising, particularly given that these BCEVs promoted inflammatory responses, DNA damage, and ROS production to a degree similar to that observed for MEL-EVs in short-term assays