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These nerves are activated by a wide range of stimuli, including food extracts (capsaicin, wasabi, ginger, allicin, mustard oil), environmental irritants (vehicle exhaust, air pollution, tobacco smoke, burning vegetation), endogenous inflammatory mediators (prostaglandin E 2 , bradykinin), and acid (Mohammed et al., 1993

Three primary human cell samples were used in this study from patients (a male aged 44 years, a male aged 41 years, and a female aged 72 years) with post-traumatic or primary hip osteoarthritis, without any known condition that could influence the bone formation capacity