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It is highly possible that tobacco smoke also contains irritants, or induces the production of endogenous metabolites that directly or indirectly activate TRPV1

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And thats what happened with the first state ban on menthol cigarettes, in Massachusetts starting in June 2020, according to research by the University of Washingtons Ali Goli and Simha Mummalaneni and Chicago Booths Pradeep K

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