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Tobacco smoke disrupts gut microbiota homeostasis driving metabolic dysfunction and multi-organ pathologies through inflammatory-metabolic axis dysregulation Tobacco smoke exposure disrupts gut microbial homeostasis, triggering metabolic dysregulation and systemic pathologies, including weight loss, cardiovascular disease, diabetes mellitus, and hepatic dysfunction through microbiota-derived inflammatory mediators and metabolite imbalances
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In 1991 and 1992, the FDA approved four transdermal nicotine patches, two of which became OTC products in 1996
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