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Smoke-free alternatives are only for adult smokers who would otherwise continue smoking

Increased abundance of Actinobacteria[p] (Beta SE: 0.051 0.019, P = 7.74e 03), Bifidobacteriales[o] (Beta SE: 0.050 0.016, P = 1.73e 03), Bifidobacteriaceae[f] (Beta SE: 0.050 0.016, P = 1.73e 03), and Bifidobacterium[g] (Beta SE: 0.049 0.016, P = 1.79e 03) lead to later smoking initiation

However, HTPs and ENDS share one commonality, they do not generate smoke, which is the primary cause of smoking related diseases and thats why we collectively refer to them as smoke-free products

Jones has no competing interests related to this work, though he has been an investigator on studies funded by AstraZeneca, Vapotherm, Abbott, and Ophirex