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Smoking cigarettes regularly can lead to long-term effects such as: Loss of taste and smell Shortness of breath Coughing fits, asthma, and lung disease Yellowing of the teeth and fingernails Stomach ulcers Heart disease Infertility Stroke and brain damage Erectile dysfunction Irregular periods or early menopause Mood swings Cancer (in many areas of the body) Insulin resistance (increasing the risk of type 2 diabetes) Financial, social, and work problems There is no safe level of Nicotine consumption as it occurs in tobacco and other smoking-related products