long term effects of tobacco Cigarette Smoking | Smoking and Use Nicotine and the cardiovascular system:

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Nicotine can feel powerful at first because it rapidly affects dopamine, acetylcholine, norepinephrine, and other neurotransmitters involved in motivation, focus, mood, and reward

Thus, it can be extrapolated that nicotine and anti-AD drugs like donepezil and memantine may share a similar transport system and compete for their transport into the brain

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