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Secondly, the study only focused on the tobacco-attributable disease burdens from 1990 to 2017 and lacked the data for smoking and chewing tobacco prevalence and SHS exposure

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5.8 Serious Skin Reactions There have been postmarketing reports of rare but serious skin reactions, including Stevens-Johnson Syndrome and erythema multiforme, in patients using CHANTIX [see Adverse Reactions (6.2)]

This causes tingling, pain and numbness that may extend down the legs mimicking sciatica symptoms