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Tooth Decay and Loss: Nicotine affects saliva production, leading to a dry mouth, which increases the risk of tooth decay and tooth loss

Japan reflects this shift, with cigarette sales falling after IQOS expanded nationally and heated tobacco products expected to account for 50% of tobacco user activity by 2025

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The current regulatory regime administered by the FDA and some individual states that ban the sale of almost all vapor devices, those that have not received approval by the FDA, or flavored products precludes a great deal of harm reduction across the US