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As Wu explained: We realized that the spontaneous differentiation of human embryonic stem cells into embryoid bodies, which consist of various lineage-specific progenitors that giving rise to the brain, heart, liver, blood vessel, muscle, and other organs, could allow us to study adverse effects of nicotine on human embryo development using 'embryoid bodies in a dish' as a surrogate for a developing fetus

Food and Drug Administration and CDC study, more than 2 million middle and high school students reported using e-cigarettes in 2021

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