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Numerous retrospective studies and meta-analyses have confirmed that a low preoperative PNI is an independent risk factor for overall complications, severe complications, pulmonary infections, and anastomotic leakage after esophagectomy (96, 97)

Reducing oxidative stress and damage from free radicals

The compound influences neurotransmitter synthesis and regulation, particularly in areas of the brain responsible for memory formation and executive function

Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice