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The range of mast cell mediators and their effects is so great that unusual presentations actually become de riguer. Lab tests can be done to check for mast cell mediators

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Tier 4 means animal data, mechanistic plausibility, or older human studies that did not show effect

46, n o 6, 704-708 (lire en ligne) DOI 10.1053/meta.2000.6250 (en) Piero Ruggenenti, Dario Cattaneo, Giacomina Loriga, Franca Ledda, Nicola Motterlini, Giulia Gherardi, Silvia Orisio et Giuseppe Remuzzi, Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk: Effects of Acetyl-L-Carnitine Therapy , Hypertension , vol