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Philp and colleagues (FASEB J, 2003) showed the LKKTETQ actin-binding site alone is sufficient to promote endothelial cell migration and angiogenesis, and Bock-Marquette and colleagues (Nature, 2004) reported activation of integrin-linked kinase and Akt with cardiomyocyte and epicardial cell migration in mouse cardiac injury models, indicating a signalling role separate from actin buffering

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Its a combination of two synthetic peptides that are known for their ability to stimulate the production of growth hormone in the body

It was hypothesized that the regulation of PD-L1 expression in cancer cells mainly interacts with the subsequent stages of the HGF/MET signaling pathway, particularly the PI3K/AKT, STAT4, and MAPK pathways [124]