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In order to limit ROS production and mitigate potential damage, cells have developed a wide range of antioxidant systems, including superoxide dismutase, catalase, glutathione peroxidase, vitamin E, and vitamin C

[22] [23] Pleiotropic effects can occur and, if DMSO control groups are not carefully planned, then solvent effects can falsely be attributed to the prospective drug

Under oxidative stress conditions, GSTM1 expression decreased while DKK3 expression increased, which was consistent with the MR results indicating GSTM1 as a protective factor and DKK3 as a risk-associated gene for cataract