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demonstrated that the E3 ubiquitin-protein ligase TRIM3 functions as a tumor suppressor by degrading SLC7A11, thereby inhibiting the tumorigenesis of non-small cell lung cancer (NSCLC) [24]

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However many antidepressants inhibit CYP2D6 to various extents, which can interfere with the conversion of tamoxifen to endoxifen 49, 50,51 (see diagram)