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Similarly, in PD, early disease stages are characterized by oxidative stress and heightened proinflammatory responses that exacerbate nigrostriatal degeneration,111,112 with Proinflammatory mediators have also been identified in the substantia nigra of postmortem PD brains.113 Systemic inflammation plays a central role in the pathophysiology of hyperinsulinemia, insulin resistance, and T2DM