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Collectively, these studies reveal the potential of PEFs to exert multi-faceted anti-tumor effects by inducing apoptosis, modulating autophagy, triggering ferroptosis, activating other RCD pathways, and potentially synergizing with chemotherapeutic drugs ( Figure 2 )

Low levels of B12 can disrupt neurotransmitter balance, potentially leading to increased anxiety and depressive symptoms

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The most commonly reported side effects in clinical trials are nausea, vomiting, diarrhoea, and constipation consistent with the gastrointestinal effects seen with GLP-1 monotherapy