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After all, how would you respond if a doctor tells you, You have either canker sores or diabetesI cant quite tell the differencebut lets treat them the same way? So, is there any scientific evidence that berberine is safe and effective way to berberine on weight loss

It's up to you

The results of the present study provide evidence that L-carnitine supplementation in pregnancy in sufficient doses avoids a striking increase of plasma FFAs, which are thought to be the main cause of insulin resistance and consequently gestational diabetes mellitus (GDM)

Curr Pharm Des 21:14041412 Brunst KJ, Baccarelli AA, Wright RJ (2015) Integrating mitochondriomics in childrens environmental health