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Most existing investigations tend to focus on either small peptides or larger bioactive peptides independently, resulting in limited data on their relative efficacy, mechanistic differences, and potential synergistic applications within the same experimental frameworks

Nature 612 , 720724 (2022)

466 A total of 3305 patients were randomly assigned to receive 120 mg of orlistat or a placebo 3 times daily

For instance, there is growing evidence that incretin therapies are not just safe but also may provide a benefit in binge-eating disorder, as they may target different reward pathways that facilitate binge-eating behaviors