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Hepatic metabolic modulation effects by GLP-1RAs GLP-1RAs replicate the action of the incretin hormone GLP-1, which primarily involves boosting insulin release, reducing glucagon secretion, and increasing feelings of fullness, ultimately leading to improved glycemic control and supporting weight management (Xu et al., 2024)

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Practical Steps to Safely Combine These Therapies Start by discussing your TRT regimen in detail with the healthcare provider overseeing your weight loss therapy

Across the STEP trials that enrolled non-diabetic participants, mean weight loss on semaglutide 2.4 mg ranged from 14.9% (STEP 1, medication alone) to 16.0% (STEP 3, medication plus behavioral therapy) at 68 weeks [1][2]