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AOD9604 alone significantly improved both gross morphological and histopathological cartilage scores versus saline controls, and the combination of AOD9604 with hyaluronic acid produced superior outcomes to either agent administered alone including significantly shorter lameness periods

Hyaluronic acid itself exists in the human skin, hyaluronic acid injection harmless to the human body, can be maintained for more than 6 months, and gradually absorbed and decomposed

The critical choice of experimental models ( in vitro , in vivo ) and biological samples (e.g., blood, sputum, BALF, EBC, cells), along with their specific considerations, are also integral to the review

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