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Pathogenic variants in the proteasome subunit, beta-type, 8 ( PSMB8 ) gene, which encodes a catalytic subunit of the 20S immunoproteasomes called 5i, has been linked to an autosomal-recessive autoinflammatory syndrome characterized by joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy (JMP syndrome) (161-163)

Third, sex differences in the OL lineage and myelination have been well described in rodents, although less so in humans 195,196

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Immune cell function is finely regulated by nutrient availability, and targeting metabolic activity is a recurrent strategy for malignant cells to proliferate