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This work was partially supported by the National Natural Science Foundation (31770796 to Y.J., 81730099 to X.X.), the National Science and Technology Major Project (2018ZX09711002-002-002) to Y.J., the National Key R&D Programs of China (2018YFA0507002), the Shanghai Municipal Science and Technology Major Project (2019SHZDZX02), the CAS Strategic Priority Research Program (XDB37030103) to H.E.X., and the Shanghai Municipal Science and Technology Commission Grant (20S11903200) to X.X

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Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway

The acetyl CoA is then used in ketogenesis