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Supporting DAO function is foundational: Vitamin C: 4001000 mg/day Vitamin B6: 3050 mg/day (as P5P ideally) Zinc: 3050 mg/day Copper: low-dose if deficient (relevant for GHK-Cu users especially) Quercetin: 5001000 mg/day acts as a mast cell stabilizer, directly reduces degranulation Genetics: Some People Are Structurally Predisposed Certain SNPs significantly impair histamine clearance this isnt a lifestyle issue, its a wiring issue: DAO variants (rs10156191, rs1049793): Reduce diamine oxidase enzyme activity and alter DAO protein structure, directly compromising the capacity to break down dietary and extracellular histamine HNMT variants (rs1050891, rs11558538): The Thr105Ile variant (rs11558538) reduces HNMT enzyme activity by approximately 50%, cutting intracellular histamine metabolism in half People carrying variants in both pathways face compounded clearance deficits

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