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Introduction# Cortistatin and DSIP represent two distinct approaches to direct sleep modulation through neuropeptide signaling

Synthetic progestins like medroxyprogesterone acetate (MPA) do carry a modest increased risk with prolonged use

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23 Diagnosis LPAC diagnosis is made based on two of three diagnostic criteria: recurrent symptoms despite cholecystectomy, presence of hyperechogenic intrahepatic foci, sludge or microlithiasis on ultrasound, and/or age of onset less than 40 years