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Figure 1 A metabolite set enrichment analysis made from the 31 metabolites significantly modulated by MTX confirmed the major impact of the drug on glycine and serine metabolism, the urea cycle, alanine metabolism, and arginine and proline metabolism ( Figure 1B )

evaluated a 2-week treatment with different doses of larazotide, ranging from 0.5 to 8 mg t.i.d., with daily gluten challenge in 86 celiac disease patients on a gluten-free diet (97)

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