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The alcohol prep, the needle insertion, and the fluid volume all contribute to local irritation

Sattar N, Lee MMY, Kristensen SL, Branch KRH, Del Prato S, Khurmi NS, Lam CSP, Lopes RD, McMurray JJV, Pratley RE, et al: Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials

This reduced hunger is intentional and helps create the calorie deficit needed for weight loss

As the evidence mounts that SFN in these populations is driven by autoimmunity, clinical trials are increasingly focusing on immune-modulating therapies