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Animal studies demonstrated that in vivo glutathione depletion directly impaired T-cell and macrophage immune function, establishing a causal relationship between glutathione status and immune competence

Zepbound is indicated for adults with obesity (with a BMI of 30 kg/m2 or greater), or those who are overweight (with a BMI of 27 kg/m2 or greater) and also have weight-related medical problems such as hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea or cardiovascular disease, to lose weight and keep it off

The study population was followed up for a duration of 36 weeks with a primary outcome of development of CIPN with a secondary outcome in this study being the Brief Pain Inventory score

Influence on IGF-1 Production Sustained increases in GH pulsatility are expected to elevate hepatic IGF-1 production, given that GH is the primary driver of IGF-1 synthesis in the liver